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Flavopiridol inhibits FOXM1/NF-kB and KRAS/MAPK signaling and DNA repair mechanims and Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin the

2026-04-10

Abstract excerpt

<title>Abstract</title> <p>Purpose Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by frequent chemoresistance and poor clinical outcomes. Doxorubicin (DOX) is a standard therapeutic agent; however, acquired resistance limits its efficacy. Forkhead box M1 (FOXM1) and nuclear factor-κB (NF-κB) are key regulators of pro-survival signaling pathways implicated in TNBC progression and drug...

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Literature Corpus work: bf409b79-9ab1-5d32-92c0-88bc5cf6f316
DOI: 10.21203/rs.3.rs-9296085/v1

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