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CENPF Knockdown Inhibits Adriamycin Chemoresistance In Triple Negative Breast Cancer Mediated By Rb-E2F1 Axis

2022-11-07

Abstract excerpt

<title>Abstract</title> <p>Background: Frequent developed resistance leads to early relapse and short survival in Triple-negative breast cancer (TNBC). Targeting DNA damage response (DDR) has become an effective strategy for overcoming TNBC chemoresistance. CENPF (centromere protein) is a key regulator of cell cycle progression, but its role in TNBC chemotherapy resistance remains unclear. <h4>Methods:</h4> We U...

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Literature Corpus work
59ef2b41-91ce-53dc-ab4e-29e7652825e7
DOI
10.21203/rs.3.rs-1853542/v2
Open publication

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