Article

Targeting FEN1 to enhance efficacy of PARP inhibition in triple-negative breast cancer

2024-10-03

Abstract excerpt

Patients with triple-negative breast cancer (TNBC) have limited targeted therapeutic options. PARP inhibitors (PARPi) have demonstrated an important role for BRCA -mutant patients with early TNBC. Combination approaches with PARPi can broaden the use of PARPi to a larger cohort of TNBC patients. We selected six genes from our previously identified 63-gene signature that was associated with PARPi response. siFEN1...

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Literature Corpus work: 4416deac-a597-52f3-8b3c-682687097c9f
DOI: 10.1101/2024.10.01.616136

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