Article

Natural and Pathogenic Protein Sequence Variation Affecting Prion-Like Domains Within and Across Human Proteomes

2019-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Protein aggregation is involved in a variety of muscular and neurodegenerative disorders. For many of these disorders, current models suggest a prion-like molecular mechanism of disease, whereby proteins aggregate and spread to neighboring cells in an infectious manner. A variety of proteins with prion-like domains (PrLDs) have recently been linked to these disorders. The development of prion pr...

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Literature Corpus work: bf37d1e7-2af8-5f93-8a02-dd587704f270
DOI: 10.1101/626648

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