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AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity

14 Jan 2019

Abstract excerpt

BACKGROUND: Around 1% of human proteins are predicted to contain a disordered and low complexity prion-like domain (PrLD). Mutations in PrLDs have been shown promote a transition towards an aggregation-prone state in several diseases. RESULTS: Recently, we have shown that an algorithm that considers the effects of mutations on PrLDs composition, as well as on localized amyloid propensity can predict the impact of...

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PMID: 30642249
DOI: 10.1186/s12859-019-2601-3

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