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Article

Manipulating the aggregation activity of human prion-like proteins.

Prion - 3 Sept 2017

Cascarina Sean M, Paul Kacy R, Ross Eric D

Abstract excerpt

Considerable advances in understanding the protein features favoring prion formation in yeast have facilitated the development of effective yeast prion prediction algorithms. Here we discuss a recent study in which we systematically explored the utility of the yeast prion prediction algorithm PAPA for designing mutations to modulate the aggregation activity of the human prion-like protein hnRNPA2B1. Mutations in...

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Identifiers

PMID: 28934062
DOI: 10.1080/19336896.2017.1356560
PMCID: PMC5639851

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