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Article

Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1.

Molecular and cellular biology - 15 Apr 2017

Paul Kacy R, Molliex Amandine, Cascarina Sean, Boncella Amy E, Taylor J Paul, Ross Eric D

Abstract excerpt

Hundreds of human proteins contain prion-like domains, which are a subset of low-complexity domains with high amino acid compositional similarity to yeast prion domains. A recently characterized mutation in the prion-like domain of the human heterogeneous nuclear ribonucleoprotein hnRNPA2B1 increases the aggregation propensity of the protein and causes multisystem proteinopathy. The mutant protein forms...

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Identifiers

PMID: 28137911
DOI: 10.1128/MCB.00652-16
PMCID: PMC5376634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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