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Genome-wide association study of proteomic aging reveals shared genetic architectures with longevity, early life development, and age-related diseases

2025-12-04

Abstract excerpt

There is still relatively little known about the genetic underpinnings of proteomic aging clocks. Here, we describe a genome-wide association study of proteomic aging in the UK Biobank (n=38,865), identifying 27 loci associated with participants’ proteomic age gap (ProtAgeGap). ProtAgeGap exhibits a strong genetic correlation with longevity (rg = −0.83), and in FinnGen a ProtAgeGap polygenic score (PGS) was associ...

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Literature Corpus work
bf288438-aa28-592f-95c0-123211a19e26
DOI
10.64898/2025.12.03.25341518
Open publication

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