Article

High-Baseline Tumor Burden–Associated Macrophages Promote Immunosuppressive Microenvironment and Restrain Immune Checkpoint Inhibitor Efficacy Through the IGFBP2–STAT3–PD-L1 Pathway

2022-01-31

Abstract excerpt

<h4>Background: </h4> In recent decades, immune checkpoint inhibitors (ICIs) have become a conspicuous promising treatment. However, there are still some problems such as limited effective rate and undefined suitable patients. With increasing attention to the influence of baseline tumor burden on the therapeutic efficacy of ICIs, most researchers are currently of the view that patients with high-baseline tumor bur...

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Literature Corpus work: be9e84da-947a-55d9-9942-825ace7c6c39
DOI: 10.21203/rs.3.rs-1304451/v1

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High-Baseline Tumor Burden–Associated Macrophages Promote Immunosuppressive Microenvironment and Restrain Immune Checkpoint Inhibitor Efficacy Through the IGFBP2–STAT3–PD-L1 PathwayDOI 10.21203/rs.3.rs-1304451/v1Read

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