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Article

Favipiravir-resistant influenza A virus shows potential for transmission

1 Jun 2021

Abstract excerpt

Favipiravir is a nucleoside analogue which has been licensed to treat influenza in the event of a new pandemic. We previously described a favipiravir resistant influenza A virus generated by in vitro passage in presence of drug with two mutations: K229R in PB1, which conferred resistance at a cost to polymerase activity, and P653L in PA, which compensated for the cost of polymerase activity. However, the clinical...

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PMID: 34061908
DOI: 10.1371/journal.ppat.1008937

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