Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.

Physiological reviews - 1 Jul 2017

Arnal Jean-Francois, Lenfant Françoise, Metivier Raphaël, Flouriot Gilles, Henrion Daniel, Adlanmerini Marine, Fontaine Coralie, Gourdy Pierre, Chambon Pierre, Katzenellenbogen Benita, Katzenellenbogen John

Abstract excerpt

Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a key role in reproduction and exerting functions in numerous nonreproductive tissues. In this review, we attempt to summarize the in vitro studies that are the basis of our current understanding of the mechanisms of action of ERα as a nuclear receptor and the key roles played by its two activation functions (AFs) in its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Estrogens

Share to Genotype

Share to Mice, Transgenic

Share to Selective Estrogen Receptor Modulators

Share to Signal Transduction

Source

Identifiers

PMID: 28539435
DOI: 10.1152/physrev.00024.2016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.PMID 28539435Read ↗

Segregation of nuclear and membrane-initiated actions of estrogen receptor using genetically modified animals and pharmacological tools.Semantic proximity Read ↗

ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.Semantic proximity Read ↗

Estrogen receptors (ER<sub>α</sub>versus ER<sub>β</sub>): friends or foes in human biology?Semantic proximity Read ↗

Reproductive phenotypes in the estrogen receptor-alpha knockout mouse.Semantic proximity Read ↗

The role of membrane ERα signaling in bone and other major estrogen responsive tissues.Semantic proximity Read ↗

Receptor null mice reveal contrasting roles for estrogen receptor alpha and beta in reproductive tissues.Semantic proximity Read ↗

The Estrogen Receptor -Isoform (ER ) of the Human Estrogen Receptor Modulates ER Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and AntiestrogensSemantic proximity Read ↗

Estrogen Receptors: How Do They Signal and What Are Their TargetsSemantic proximity Read ↗

Estrogen receptor knockout mice: phenotypes in the female reproductive tract.Semantic proximity Read ↗

Selected Phytoestrogens Distinguish Roles of ERα Transactivation and Ligand Binding for Anti-Inflammatory Activity.Semantic proximity Read ↗

Estrogen receptor transcription and transactivation: Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action.Semantic proximity Read ↗

The emerging role of estrogen's non-nuclear signaling in the cardiovascular diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.