Article

The Positive Feedback Loop Between RLIP76 and HIF-1α Promotes Glycolysis and Tumorigenesis in Glioma Cells Under Hypoxic Conditions

2020-09-24

Abstract excerpt

<h4>Background: </h4> Hypoxia is intimately associated with increased glycolysis in gliomas, and HIF-1α plays a critical role in this process. Here, we aim to show that RLIP76 is a novel target of HIF-1α and is involved in hypoxia-enhanced glycolysis in glioma cells. MethodsThe human glioma cell lines U87 and U251 were used to explore the interactions of RLIP76-HIF-1α and RLIP76-VHL using Western blot, a Biotin pu...

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Literature Corpus work: be3c6020-b0f7-5397-8bd2-aa78f85266e7
DOI: 10.21203/rs.3.rs-76244/v1

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