Article

Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway

2024-12-10

Abstract excerpt

The peripheral nervous system (PNS) plays a critical role in pathological conditions, including chronic pain disorders, that manifest differently in men and women. To investigate this sexual dimorphism at the molecular level, we integrated quantitative proteomic profiling of human dorsal root ganglia (hDRG) and peripheral nerve tissue into the expanding omics framework of the PNS. Using data-independent acquisitio...

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Literature Corpus work: be1d9a0f-57b7-5b98-8d9c-e007504e08e8
DOI: 10.1101/2024.12.06.626968

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