Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.

Nature cell biology - 1 Aug 2018

Beumer Joep, Artegiani Benedetta, Post Yorick, Reimann Frank, Gribble Fiona, Nguyen Thuc Nghi, Zeng Hongkui, Van den Born Maaike, Van Es Johan H, Clevers Hans

Abstract excerpt

Enteroendocrine cells (EECs) control a wide range of physiological processes linked to metabolism1. We show that EEC hormones are differentially expressed between crypts (for example, Glp1) and villi (for example, secretin). As demonstrated by single-cell mRNA sequencing using murine Lgr5+ cell-derived organoids, BMP4 signals alter the hormone expression profiles of individual EECs to resemble those found in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 4
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Cell Movement

Share to Intestine, Small

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 30038251
DOI: 10.1038/s41556-018-0143-y
PMCID: PMC6276989

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.PMID 30038251Read ↗

Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal developmentSemantic proximity Read ↗

Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profilingSemantic proximity Read ↗

Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epitheliumSemantic proximity Read ↗

A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell TranscriptomicsSemantic proximity Read ↗

BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell statesSemantic proximity Read ↗

A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomicsSemantic proximity Read ↗

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animalsSemantic proximity Read ↗

ETV1 is a key regulator of enteroendocrine PYY production.Semantic proximity Read ↗

Insulin is expressed by enteroendocrine cells during human fetal developmentSemantic proximity Read ↗

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestineSemantic proximity Read ↗

A Development-Inspired Niche for Homeostatic Human Mini-IntestinesSemantic proximity Read ↗

The Intestinal Epithelium – Fluid Fate and Rigid Structure From Crypt Bottom to Villus TipSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.