Article

Topological and Enzymatic Analysis of Human Alg2 Mannosyltransferase

2021-09-15

Abstract excerpt

<title>Abstract</title> <p>N-glycosylation starts with the biosynthesis of lipid-linked oligosaccharide (LLO) on the endoplasmic reticulum. Alg2 mannosyltransferase adds both the α1,3- and α1,6-Man onto ManGlcNAc2-pyrophosphate-dolichol (M1Gn2-PDol) in either order to generate the branched M3Gn2-PDol product. The well-studied yeast Alg2 interacts with ER membrane through four hydrophobic domains. Unexpectedly, we...

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Literature Corpus work: be0c3881-4feb-5ddf-953b-bf6ac0c2646b
DOI: 10.21203/rs.3.rs-871713/v1

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