Article
Alg14 organizes the formation of a multiglycosyltransferase complex involved in initiation of lipid-linked oligosaccharide biosynthesis.
Glycobiology - 1 Apr 2012
Lu Jishun, Takahashi Tetsuo, Ohoka Atsuko, Nakajima Kei-ichi, Hashimoto Ryo, Miura Nobuaki, Tachikawa Hiroyuki, Gao Xiao-Dong
Abstract excerpt
Protein N-glycosylation begins with the assembly of a lipid-linked oligosaccharide (LLO) on the endoplasmic reticulum (ER) membrane. The first two steps of LLO biosynthesis are catalyzed by a functional multienzyme complex comprised of the Alg7 GlcNAc phosphotransferase and the heterodimeric Alg1...
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