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Article

Structure and mechanism of the ER-based glucosyltransferase ALG6.

Nature - 1 Mar 2020

Bloch Joël S, Pesciullesi Giorgio, Boilevin Jérémy, Nosol Kamil, Irobalieva Rossitza N, Darbre Tamis, Aebi Markus, Kossiakoff Anthony A, Reymond Jean-Louis, Locher Kaspar P

Abstract excerpt

In eukaryotic protein N-glycosylation, a series of glycosyltransferases catalyse the biosynthesis of a dolichylpyrophosphate-linked oligosaccharide before its transfer onto acceptor proteins1. The final seven steps occur in the lumen of the endoplasmic reticulum (ER) and require dolichylphosphate-activated mannose and glucose as donor substrates2. The responsible enzymes-ALG3, ALG9, ALG12, ALG6, ALG8 and...

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Identifiers

PMID: 32103179
DOI: 10.1038/s41586-020-2044-z
PMCID: PMC8712213

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Structure and mechanism of the ER-based glucosyltransferase ALG6.PMID 32103179Read ↗

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