Article

Improvement of 5-Fluorouracil Chemosensitivty In Colorectal Cancer Cells by siRNA-Mediated Silencing of STAT6 Oncogene

2022-11-04

Abstract excerpt

<h4>Background: </h4> One of the cancers that occur most frequently around the world is colorectal cancer (CRC). STAT6 transcription factor is involved in cellular multipotency, tumor cell growth, drug resistance, stemness, and migration, showing potential as a cancer therapy target for a variety of cancers, including CRC. In this regard, the current study aimed to investigate the effect of STAT6 silencing via sma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdb5abcd-5575-51a8-a165-d6e9b4fea9a8
DOI: 10.21203/rs.3.rs-2150435/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Improvement of 5-Fluorouracil Chemosensitivty In Colorectal Cancer Cells by siRNA-Mediated Silencing of STAT6 OncogeneDOI 10.21203/rs.3.rs-2150435/v1Read

Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugsSemantic proximity Read

Molecular and phenotypic characterization of 5-FU resistant colorectal cancer cells: toward enrichment of cancer stem cellsSemantic proximity Read

Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6Semantic proximity Read

The effects of mesenchymal stem cells on the chemotherapy of colorectal cancerSemantic proximity Read

Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathwaySemantic proximity Read

Fluorouracil modulates the genome of HCT116 colorectal cancer cells as revealed by whole exome sequencingSemantic proximity Read

SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25ASemantic proximity Read

Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and CisplatinSemantic proximity Read

Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cellsSemantic proximity Read

Gracillin shows potent efficacy against colorectal cancer through inhibiting the STAT3 pathwaySemantic proximity Read

The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancerSemantic proximity Read

Cancer stem cell–associated miRNAs serve as prognostic biomarkers in colorectal cancerSemantic proximity Read