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Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells

20 May 2022

Abstract excerpt

BACKGROUND: The uncontrolled proliferation of cancer cells determines hypoxic conditions within the neoplastic mass with consequent activation of specific molecular pathways that allow cells to survive despite oxygen deprivation. The same molecular pathways are often the cause of chemoresistance. This study aims to investigate the role of the hypoxia-induced miR-675-5p in 5-Fluorouracil (5-FU) resistance on...

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PMID: 35596172
DOI: 10.1186/s12885-022-09666-2

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