Article

KDM5A/B promotes HIV-1 latency and KDM5 inhibitors promote HIV-1 lytic reactivation

2022-11-17

Abstract excerpt

Combinational antiretroviral therapy (cART) effectively suppresses HIV-1 infection, replication, and pathogenesis in HIV-1 patients. However, the patient’s HIV-1 reservoir still cannot be eliminated by current cART or other therapies. One putative HIV-1 eradication strategy is “shock and kill”, which reactivates HIV-1 in latently-infected cells and induces their cytopathic effect or immune clearance to decrease th...

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Literature Corpus work: bda398d5-e3a6-5a4e-ae55-1943ea21f62a
DOI: 10.1101/2022.11.17.516956

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