Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukemia

Abstract excerpt

Acute myeloid leukemia (AML) is a hematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterized as a regulator of the cell cycle and differentiation in the myeloid lineage. Recent evidence has demonstrated that NFAT family members may have roles in regulating AML leukemogenesis and resist...

Topics

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• Acute Myeloid Leukemia Research
• Apoptosis
• Hematopoiesis
• Histone Deacetylase Inhibitors Research
• Kruppel-like factors research
• Mutation
• NF-κB Signaling Pathways
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

bd7e4ca8-5dd2-5235-861a-73b93ac1b6e4

DOI

10.20944/preprints202107.0421.v1