Article

<i>MYC–NFATC2 axis</i> maintains cell cycle and mitochondrial function in AML cells

2023-11-17

Abstract excerpt

Acute myeloid leukaemia (AML) is a clonal haematological malignancy affecting the myeloid lineage with generally poor patient outcomes, owing to the lack of targeted therapies. The histone lysine demethylase 4A (KDM4A) has been established as a novel therapeutic target in AML, due to its selective oncogenic role within leukaemic cells. We identify that the transcription factor NFATC2 is a novel binding and transc...

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Literature Corpus work: d0f0077b-7f79-56b8-95f8-22ccae02e600
DOI: 10.1101/2023.11.15.567209

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