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Article

Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cells

2020-06-12

Abstract excerpt

Immune checkpoint immunotherapy is a pillar of human oncology treatment with potential for non-human species. The first checkpoint immunotherapy approved for human cancers targeted the CTLA4 protein. CTLA4 can inhibit T cell activation by capturing and internalizing CD80 and CD86 from antigen presenting cells, a process called trans-endocytosis. Similarly, CD28 can capture CD80 and CD86 via trogocytosis and retain...

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Identifiers and source

Literature Corpus work
bd7a726f-ecdc-5abb-8732-e4acdb3248b9
DOI
10.1101/2020.06.11.145789
Open publication

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Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cellsDOI 10.1101/2020.06.11.145789
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