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The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

2018-04-12

Abstract excerpt

<h4>Summary</h4> The marsupial Tasmanian devil ( Sarcophilus harrisii ) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the molecular underpinnings of DFTD, we designed an approach that combines sensitivity to drugs with an integrated systems-biology characterization. Sensitivity to inhibitors of the ERBB family of receptor tyrosine kinases correlated with their overexpression,...

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Literature Corpus work
2c7b24d1-5ad5-53be-a72a-8c74a055e0d1
DOI
10.1101/283309
Open publication

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