Article
Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia.
The Journal of clinical investigation - 17 Jun 2024
Ramdas Baskar, Dayal Neetu, Pandey Ruchi, Larocque Elizabeth, Kanumuri Rahul, Pasupuleti Santhosh Kumar, Liu Sheng, Kanellopoulou Chrysi, Chu Elizabeth Fei Yin, Mohallem Rodrigo, Virani Saniya, Chopra Gaurav, Aryal Uma K, Lapidus Rena, Wan Jun, Emadi Ashkan, Haneline Laura S, Holtsberg Frederick W, Aman M Javad, Sintim Herman O, Kapur Reuben
Abstract excerpt
Activating mutations of FLT3 contribute to deregulated hematopoietic stem and progenitor cell (HSC/Ps) growth and survival in patients with acute myeloid leukemia (AML), leading to poor overall survival. AML patients treated with investigational drugs targeting mutant FLT3, including Quizartinib and Crenolanib, develop resistance to these drugs. Development of resistance is largely due to acquisition of...
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