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Article

Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia.

Cancer research - 2 Apr 2026

Eriksson Johanna, Zheng Shuyu, Popa Mihaela, Bao Jie, Dai Jun, Wang Wenyu, McCormack Emmet, Vähärautio Anna, Tang Jing

Abstract excerpt

Whereas FMS-like tyrosine kinase-3 (FLT3) inhibitors have significantly improved the treatment of aggressive FLT3-mutated acute myeloid leukemia (AML), the emergence of resistance remains as a major challenge. In this study, we applied our recently developed single-cell lineage-tracing method ReSisTrace to identify cells that are intrinsically resistant or sensitive to the FLT3 inhibitors midostaurin and...

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Source

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Identifiers

PMID: 41270153
DOI: 10.1158/0008-5472.CAN-24-3753
PMCID: PMC7618455

Genes

FLT3
GSPT1
IGF1R
INSR
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia.PMID 41270153Read ↗

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