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Article

FLT3 inhibitors: clinical potential in acute myeloid leukemia

1 Feb 2017

Abstract excerpt

Abstract: Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy that is cured in as few as 15%–40% of cases. Tremendous improvements in AML prognostication arose from a comprehensive analysis of leukemia cell genomes. Among normal karyotype AML cases, mutations in the FLT3 gene are the ones most commonly detected as having a deleterious prognostic impact. FLT3 is a transmembrane tyrosine kinase...

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PMID: 28223820
DOI: 10.2147/ott.s103790

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