Article

GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia

2023-07-26

Abstract excerpt

<h4>Background: </h4> Acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation accounts for a large proportion of AML patients and diagnosed with dismay prognosis. Although the prognosis of FLT3-ITD AML has been greatly improved, the drug resistance frequently occurred in the treatment of FLT3 target drugs. GNF-7, a multitargeted kinase inhibitor, which provided...

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Literature Corpus work: a2284937-6cd1-55c4-88dc-f55bb49e978f
DOI: 10.21203/rs.3.rs-3190882/v1

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