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Reversible and Causal Epigenetic Information Loss in Liver Aging and Disease

2025-02-27

Abstract excerpt

The loss of epigenetic information has been proposed as a driver of aging and diseases, but the reversibility and causality of this process remain underexplored. Here we analyze liver-unique methylation sites - genomic loci that show distinct methylation patterns in the liver compared to other tissues. Upon disease progression, these sites overwhelmingly regress toward the pan-tissue average. In addition, we demon...

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Identifiers and source

Literature Corpus work
bd61075e-4386-5e08-901b-d4fd8055e47d
DOI
10.1101/2025.02.24.639802
Open publication

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Reversible and Causal Epigenetic Information Loss in Liver Aging and DiseaseDOI 10.1101/2025.02.24.639802
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