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Article

Obesity accelerates epigenetic aging of human liver

13 Oct 2014

Abstract excerpt

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an "epigenetic clock") to study the relationship between high body mass index (BMI) and the DNA methylation ages of human blood, liver, muscle, and adipose tissue. A significant correlation between BMI and epigenetic age...

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PMID: 25313081
DOI: 10.1073/pnas.1412759111

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