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Epigenetic Alterations in Blood Mirror Age-Associated Dna Methylation and Gene Expression Changes in Human Liver

2 Dec 2016

Abstract excerpt

AIM: To study the impact of aging on DNA methylation and mRNA expression in human liver. EXPERIMENTAL PROCEDURES: We analysed genome-wide DNA methylation and gene expression in human liver samples using Illumina 450K and HumanHT12 expression BeadChip arrays. RESULTS: DNA methylation analysis of ∼455,000 CpG sites in human liver revealed that age was significantly associated with altered DNA methylation of 20,396...

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PMID: 27911095
DOI: 10.2217/epi-2016-0087

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