Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature

15 Mar 2018

Abstract excerpt

The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of liver biopsies collected from 45 healthy liver donors ranging from 13 to 90 years old using the Infinium HumanMethylation450 BeadChip. The analysis indicates that a large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation
Share to Organ Transplantation Techniques and Outcomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29554203
DOI: 10.1093/gerona/gly048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic SignaturePMID 29554203Read ↗

Epigenetic Alterations in Blood Mirror Age-Associated Dna Methylation and Gene Expression Changes in Human LiverSemantic proximity Read ↗

The peculiar aging of human liver: A geroscience perspective within transplant contextSemantic proximity Read ↗

Obesity accelerates epigenetic aging of human liverSemantic proximity Read ↗

Epigenetics in liver disease: from biology to therapeuticsSemantic proximity Read ↗

Reversible and Causal Epigenetic Information Loss in Liver Aging and DiseaseSemantic proximity Read ↗

Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression TrajectoriesSemantic proximity Read ↗

Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age accelerationSemantic proximity Read ↗

Epigenetic reprogramming in liver fibrosis and cancerSemantic proximity Read ↗

DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitisSemantic proximity Read ↗

Unraveling the Epigenetic Basis of Liver Development, Regeneration and DiseaseSemantic proximity Read ↗

Repurposing GLP-1 Receptor Agonists: A Perspective on Epigenetic Strategies to Combat Fibrosis and Hepatocellular Carcinoma in the Aged LiverSemantic proximity Read ↗

Epigenetic modification in alcohol‐related liver diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.