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MoDorado: Enhanced detection of tRNA modifications in nanopore sequencing by off-label use of modification callers

2025-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Rapid and accurate identification of tRNA modifications is crucial for understanding their role in protein translation and disease. However, their detection on tRNAs is challenging due to their high modification density. Recently, modification calling models for nanopore direct RNA sequencing became available for pseudouridine (Ψ), m 6 A, inosine and m 5 C, as part of the Dorado basecaller. Ap...

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Literature Corpus work: bd48fc72-746e-51d9-99e2-11a3e39738d9
DOI: 10.1101/2025.02.18.638820

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