Article

Single-cell profiling reveals monocyte mitochondrial dysfunction in patients with cirrhosis progressing to acute-on-chronic liver failure

2025-02-07

Abstract excerpt

Patients with acute decompensation (AD) of cirrhosis face a high risk of acute-on-chronic liver failure (ACLF), a syndrome linked to multiple organ failure and high mortality. This study analyzed peripheral blood mononuclear cells (PBMCs) using single-cell technologies to explore their role in patient outcomes. Blood samples from 15 healthy donors and 63 AD patients were prospectively collected at hospital admissi...

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Literature Corpus work: bd47abeb-2227-582e-a9d0-b464b7431ad0
DOI: 10.1101/2025.02.04.25321370

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Single-cell profiling reveals monocyte mitochondrial dysfunction in patients with cirrhosis progressing to acute-on-chronic liver failureDOI 10.1101/2025.02.04.25321370Read

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