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Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome

18 Jun 2020

Abstract excerpt

Acute respiratory distress syndrome (ARDS) results from overwhelming pulmonary inflammation. Prior bulk RNA sequencing provided limited insights into ARDS pathogenesis. We used single cell RNA sequencing to probe ARDS at a higher resolution. PBMCs of patients with pneumonia and sepsis with early ARDS were compared with those of sepsis patients who did not develop ARDS. Monocyte clusters from ARDS patients...

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PMID: 32554932
DOI: 10.1172/jci.insight.135678

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