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De-ubiquitination of SAMHD1 by USP7 overcomes oncogenic stress and contributes to chemotherapy insensitivity

2021-08-20

Abstract excerpt

<title>Abstract</title> <p>Oncogenic stress induces DNA damage response (DDR) that guards against genetic instability during the evolution of cancer. SAMHD1, a dNTPase protecting cells from viral infections, has been recently found to participate in DNA damage repair process. However, its role in tumorigenesis remains largely unknown. Here, we show that SAMHD1 is up-regulated in early-stage human carcinoma tissue...

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Literature Corpus work
bd1ad6dd-74a6-5e7b-af22-9ce369293cae
DOI
10.21203/rs.3.rs-763082/v1
Open publication

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De-ubiquitination of SAMHD1 by USP7 overcomes oncogenic stress and contributes to chemotherapy insensitivityDOI 10.21203/rs.3.rs-763082/v1
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