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Article

Ratio of the interferon- <i>γ</i> signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

2020-04-18

Abstract excerpt

Immune checkpoint inhibitor (ICI) treatments produce clinical benefit in many patients. However, better pretreatment predictive biomarkers for ICI are still needed to help match individual patients to the treatment most likely to be of benefit. Existing gene expression profiling (GEP)-based biomarkers for ICI are primarily focused on measuring a T cell-inflamed tumour microenvironment that contributes positively t...

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Literature Corpus work
3944a610-e86a-5048-981f-b577e492d35a
DOI
10.1101/2020.04.18.047852
Open publication

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Ratio of the interferon- <i>γ</i> signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanomaDOI 10.1101/2020.04.18.047852
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