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Article

Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.

The Journal of biological chemistry - 27 Apr 2007

Kohlhaas Susan L, Craxton Andrew, Sun Xiao-Ming, Pinkoski Michael J, Cohen Gerald M

Abstract excerpt

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is selectively toxic to tumor compared with normal cells. Other members of the TNF family of death ligands (TNF, CD95L) engage their respective receptors (TNF-R1 and CD95), resulting in internalization of receptor and ligand and recruitment of adaptor proteins to the caspase activation platform known as the death-inducing signaling complex...

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Identifiers

PMID: 17327223
DOI: 10.1074/jbc.M700438200

Genes

TNF
FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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