Article

EFF-1 promotes muscle fusion, paralysis and retargets infection by AFF-1-coated viruses in <i>C. elegans</i>

2020-05-17

Abstract excerpt

A hallmark of muscle development is that myoblasts fuse to form myofibers. However, smooth muscles and cardiomyocytes do not generally fuse. In C. elegans , the body wall muscles (BWMs), the physiological equivalents of skeletal muscles, are mononuclear. Here, to determine what would be the consequences of fusing BWMs, we express the cell-cell fusogen EFF-1 in these cells. We find that EFF-1 induces paralysis and...

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Literature Corpus work: bcd5ab06-1f76-5e58-9e55-faa9f435e712
DOI: 10.1101/2020.05.17.099622

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