Article
Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion.
Nature communications - 15 Jan 2026
Zhang Haifeng, Shang Renjie, Zhang Zheng, Zhou Min, Bigot Anne, Cai Yanqing, Zhao Yanran, Wang Yushu, Deshmukh Aaryahi, Kudryashova Elena, Kudryashov Dmitri S, He Cuiyu, Mouly Vincent, Bi Pengpeng
Abstract excerpt
Muscle defects are common in human developmental disorders and often cause severe functional impairment. These defects arise from intricate tissue crosstalk and rare genetic mutations, underscoring the need to systematically identify cell-autonomous mechanisms regulating human myogenesis. Here we show a rationally designed, high-throughput genetic screening platform that integrates human myoblast models,...
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