Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on the host in a gut microphysiological system

Abstract excerpt

Hydrogen sulfide (H 2 S) is a gaseous microbial metabolite whose role in gut diseases is debated, with contradictory results stemming from experimental difficulties associated with accurate dosing and measuring H 2 S and the use of model systems that do not accurately represent the human gut environment. Here, we engineer Escherichia coli to titrate H 2 S across the physiological range in a gut microphysiological...

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