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Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on host in a gut microphysiological system

2023-05-16

Abstract excerpt

Hydrogen sulfide (H 2 S) is a gaseous microbial metabolite whose role in gut diseases is debated, largely due to the difficulty in controlling its concentration and the use of non-representative model systems in previous work. Here, we engineered E. coli to titrate H 2 S controllably across the physiological range in a gut microphysiological system (chip) supportive of the co-culture of microbes and host cells....

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Literature Corpus work: 6ccc6c28-3ec0-5acb-9305-b364dcacd1fb
DOI: 10.1101/2023.05.16.538950

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