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Article

Inhibition of Nonfunctional Ras.

Cell chemical biology - 18 Feb 2021

Nussinov Ruth, Jang Hyunbum, Gursoy Attila, Keskin Ozlem, Gaponenko Vadim

Abstract excerpt

Intuitively, functional states should be targeted; not nonfunctional ones. So why could drugging the inactive K-Ras4BG12Cwork-but drugging the inactive kinase will likely not? The reason is the distinct oncogenic mechanisms. Kinase driver mutations work by stabilizing the active state and/or destabilizing the inactive state. Either way, oncogenic kinases are mostly in the active state. Ras driver mutations work...

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Identifiers

PMID: 33440168
DOI: 10.1016/j.chembiol.2020.12.012
PMCID: PMC7897307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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