Article
A distal regulatory region of a class I human histone deacetylase.
Nature communications - 31 Jul 2020
Werbeck Nicolas D, Shukla Vaibhav Kumar, Kunze Micha B A, Yalinca Havva, Pritchard Ruth B, Siemons Lucas, Mondal Somnath, Greenwood Simon O R, Kirkpatrick John, Marson Charles M, Hansen D Flemming
Abstract excerpt
Histone deacetylases (HDACs) are key enzymes in epigenetics and important drug targets in cancer biology. Whilst it has been established that HDACs regulate many cellular processes, far less is known about the regulation of these enzymes themselves. Here, we show that HDAC8 is allosterically regulated by shifts in populations between exchanging states. An inactive state is identified, which is stabilised by a...
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