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Article

Impact of Pharmacokinetic Gene Polymorphisms on Statin-Induced Myotoxicity in Thai Patients Treated With Simvastatin.

Clinical and translational science - 1 Apr 2026

Tipnoppanon Sayanit, Siwamogsatham Sarawut, Vorasettakarnkij Yongkasem, Sukasem Chonlaphat, Chariyavilaskul Pajaree, Satapornpong Patompong, Vanwong Natchaya

Abstract excerpt

Statin-induced myotoxicity (SIM) is a common adverse effect of simvastatin therapy, which can negatively impact patient adherence and treatment outcomes. This study aims to investigate the impacts of pharmacokinetic (PK) gene polymorphisms on SIM in Thai population treated with simvastatin. One hundred forty-eight Thai participants, including 23 with SIM and 125 tolerant controls were enrolled. The...

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Source

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Identifiers

PMID: 41860236
DOI: 10.1111/cts.70528
PMCID: PMC13140828

Genes

SLCO1B1
ABCC2
ABCB1
ABCG2
CYP3A4
CYP3A5
SLCO1B3

Variants

rs4149056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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