Article

Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.1 and BA.2 variants and their mouse origins

2022-04-13

Abstract excerpt

<h4>ABSTRACT</h4> The Omicron BA.2 variant has become a dominant infective strain worldwide. Receptor binding studies reveal that the Omicron BA.2 spike trimer have 11-fold and 2-fold higher potency to human ACE2 than the spike trimer from the wildtype (WT) and Omicron BA.1 strains. The structure of the BA.2 spike trimer complexed with human ACE2 reveals that all three receptor-binding domains (RBDs) in the spike...

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Literature Corpus work: bc029d6e-7be5-50c9-b073-f5d74b782748
DOI: 10.1101/2022.04.12.488075

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