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Mutations in the SARS-CoV-2 spike proteins affected the ACE2-binding affinity during the development of Omicron pandemic variants.

Biochemical and biophysical research communications - 30 Jul 2024

Tachibana Kouichi, Nakamura Yoshihiko, Do Thi Ly, Kihara Takanori, Kawada Hiroshi, Yamamoto Norio, Ando Kiyoshi

Abstract excerpt

Mutations in SARS-CoV-2 caused multiple waves of pandemics. To identify the function of such mutations, we investigated the binding affinity of the S protein with its receptor, ACE2. Omicron BA.1 showed significantly lower binding affinity with human ACE2 than prototype SARS-CoV-2 and Alpha strain, indicating that pre-Omicron to Omicron transition was not mediated by increasing the ACE2-binding affinity....

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PMID: 38759524
DOI: 10.1016/j.bbrc.2024.150120

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