Article

Predictive Models of Genome-wide Aryl Hydrocarbon Receptor DNA Binding Reveal Tissue Specific Binding Determinants

2022-05-13

Abstract excerpt

<h4>Background</h4> The Aryl Hydrocarbon Receptor (AhR) is an inducible transcription factor (TF) whose ligands include the environmental contaminant 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD). TCDD-mediated toxicity occurs through activation of AhR and its subsequent binding to the Dioxin Response Element (DRE), comprising the DNA motif 5’-GCGTG-3’. However, AhR binding in human tissues is highly dynamic and...

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Literature Corpus work: bbff5bb3-78e7-5976-b164-2d64bbd5e8b2
DOI: 10.1101/2022.05.13.491754

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