Article

Repertoire analysis of antibody CDR-H3 loops suggests affinity maturation does not typically result in rigidification

2017-12-08

Abstract excerpt

Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to understanding B-cell immunity. An emergent hypothesis is that affinity maturation reduces the conformational flexibility of...

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Literature Corpus work: bb630f9a-7c55-5820-9eda-55edc23ef3b5
DOI: 10.1101/230417

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