Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

Abstract excerpt

Fab consist of a heavy and light chain and can be subdivided into a variable (VHand VL) and a constant region (CH1 and CL). The variable region contains the complementarity-determining region (CDR), which is formed by six hypervariable loops, shaping the antigen binding site, the paratope. Apart from the CDR loops, both the elbow angle and the relative interdomain orientations of the VH–VLand the CH1–CLdomains...

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